Glibenclamide enhances isoproterenol-induced vasorelaxation in the porcine coronary artery.
نویسندگان
چکیده
منابع مشابه
Enhanced b-receptor-mediated vasorelaxation in hypoxic porcine coronary artery
Fukuda, Satoru, Takashi Toriumi, Hui Xu, Hidenori Kinoshita, Hironobu Nishimaki, Seiichiro Kokubun, Naoshi Fujiwara, Hideyoshi Fujihara, and Koki Shimoji. Enhanced b-receptor-mediated vasorelaxation in hypoxic porcine coronary artery. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1447–H1452, 1999.—To investigate the b-adrenoceptor-mediated responses in hypoxic coronary arteries, we studied th...
متن کاملEnhanced β-receptor-mediated vasorelaxation in hypoxic porcine coronary artery.
To investigate the β-adrenoceptor-mediated responses in hypoxic coronary arteries, we studied the effect of isoproterenol (Iso) on isolated porcine coronary arteries contracted with endothelin-1 in media aerated with 0, 5, 7.5, and 95% O2. The concentration-response curve of Iso was significantly shifted to the left by hypoxia (0 and 5% O2). In oxygenated and hypoxic arteries, 3 × 10-8, 10-6, a...
متن کاملMechanisms of vasorelaxation induced by troglitazone, a novel antidiabetic drug, in the porcine coronary artery.
BACKGROUND Troglitazone (TRO), a novel antidiabetic drug, has been reported to decrease blood pressure and relax vascular strips. The mechanism of relaxation induced by TRO was determined in terms of Ca2+ signaling in smooth muscle cells. METHODS AND RESULTS Front-surface fluorometry and fura 2-loaded medial strips of porcine coronary artery were used to examine the effects of TRO on cytosoli...
متن کاملThe effects of ATP-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in rats
Objective(s): Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (KATP) channel blocker (gl...
متن کاملPorcine Coronary Artery
coronary artery contraction evoked by thromboxane A2 (TXA2) were studied in vitro. Ring preparations of porcine proximal coronary artery were suspended in a Magnus apparatus filled with Tyrode's solution at 370 C and aerated with 100%0 02, and the isometric tension of the contractions was measured. Insulin itself caused neither contraction nor relaxation. Insulin had no significant effect on th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)39367-9